Understanding the physical principles that govern the structure and function of biological molecules is paramount to predict and rationalize biological activity. To this end, we use computer simulations to study biological systems at the molecular level. Currently the laboratory is engaged in three main directions of research.

• We are studying the solvation, folding, and self-aggregation of peptides and proteins.
• We are developing novel computational methods for the prediction of protein-ligand binding affinities to help in the discovery of new therapeutic agents (rational drug design).
• We are studying the molecular mechanism of proton transport across biological membranes, a process which is essential to life itself (respiration, metabolism).

We're currently developing an updated Pomes Lab website, but the old site is available here.